A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CL(pro) inhibitor PF-00835231 as a potential new treatment for COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of Coronavirus Disease 2019 (COVID-19). There is a dire need for novel effective antivirals to treat COVID-19, as the only approved direct-acting antiviral to date is remdesivir, targeting the viral polymerase comp...

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Udgivet i:bioRxiv
Main Authors: de Vries, Maren, Mohamed, Adil S, Prescott, Rachel A, Valero-Jimenez, Ana M, Desvignes, Ludovic, O’Connor, Rebecca, Steppan, Claire, Devlin, Joseph C, Ivanova, Ellie, Herrera, Alberto, Schinlever, Austin, Loose, Paige, Ruggles, Kelly, Koralov, Sergei B, Anderson, Annaliesa S., Binder, Joseph, Dittmann, Meike
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457613/
https://ncbi.nlm.nih.gov/pubmed/32869028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.28.272880
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