Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

Identification of host genes essential for SARS-CoV-2 infection may reveal novel therapeutic targets and inform our understanding of COVID-19 pathogenesis. Here we performed a genome-wide CRISPR screen with SARS-CoV-2 and identified known SARS-CoV-2 host factors including the receptor ACE2 and prote...

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Vydáno v:bioRxiv
Hlavní autoři: Wei, Jin, Alfajaro, Mia Madel, Hanna, Ruth E., DeWeirdt, Peter C., Strine, Madison S., Lu-Culligan, William J., Zhang, Shang-Min, Graziano, Vincent R., Schmitz, Cameron O., Chen, Jennifer S., Mankowski, Madeleine C., Filler, Renata B., Gasque, Victor, de Miguel, Fernando, Chen, Huacui, Oguntuyo, Kasopefoluwa, Abriola, Laura, Surovtseva, Yulia V., Orchard, Robert C., Lee, Benhur, Lindenbach, Brett, Politi, Katerina, van Dijk, David, Simon, Matthew D., Yan, Qin, Doench, John G., Wilen, Craig B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457610/
https://ncbi.nlm.nih.gov/pubmed/32869025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.16.155101
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