Theoretical basis for stabilizing messenger RNA through secondary structure design

RNA hydrolysis presents problems in manufacturing, long-term storage, world-wide delivery, and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics. A largely unexplored strategy to reduce mRNA hydrolysis is to redesign RNAs to form double-stranded regions, which are protected f...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Wayment-Steele, Hannah K., Kim, Do Soon, Choe, Christian A., Nicol, John J., Wellington-Oguri, Roger, Watkins, Andrew M., Sperberg, R. Andres Parra, Huang, Po-Ssu, Participants, Eterna, Das, Rhiju
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457604/
https://ncbi.nlm.nih.gov/pubmed/32869022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.22.262931
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados