Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

SARS-CoV-2 has resulted in a global pandemic and shutdown economies around the world. Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin cleavage site (PRRAR) in its spike protein. Absent in other group 2B CoVs, the insertion may be a key factor in the replicati...

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Publicado no:bioRxiv
Main Authors: Johnson, Bryan A., Xie, Xuping, Kalveram, Birte, Lokugamage, Kumari G., Muruato, Antonio, Zou, Jing, Zhang, Xianwen, Juelich, Terry, Smith, Jennifer K., Zhang, Lihong, Bopp, Nathen, Schindewolf, Craig, Vu, Michelle, Vanderheiden, Abigail, Swetnam, Daniele, Plante, Jessica A., Aguilar, Patricia, Plante, Kenneth S., Lee, Benhur, Weaver, Scott C., Suthar, Mehul S., Routh, Andrew L., Ren, Ping, Ku, Zhiqiang, An, Zhiqiang, Debbink, Kari, Shi, Pei Yong, Freiberg, Alexander N., Menachery, Vineet D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457603/
https://ncbi.nlm.nih.gov/pubmed/32869021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.26.268854
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