Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α

BACKGROUND: Metabolic remodeling plays a vital role in the development of heart failure. The trimetazidine can optimize fatty acid and glucose oxidation via inhibition of long-chain 3-ketoacyl CoA thiolase in the heart. So, trimetazidine commonly used in cardiovascular therapy as a myocardial metabo...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Li, Huihui, Ma, Zhi, Zhai, Yajun, Lv, Chao, Yuan, Peng, Zhu, Feng, Wei, Liping, Li, Qi, Qi, Xin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2020
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457052/
https://ncbi.nlm.nih.gov/pubmed/32922293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01255
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