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Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons
Oxidative stress is an important mechanism of neonatal hypoxic-ischemic brain damage. Sirtuin1 (Sirt1) is a deacetylase that depends on NAD(+), which has an important role in antioxidant metabolism. Furthermore, peroxisome proliferator-activated receptor γ-co-activator 1α (PGC-1α) is a key regulator...
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| Publié dans: | Front Pediatr |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Frontiers Media S.A.
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7456989/ https://ncbi.nlm.nih.gov/pubmed/32923413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fped.2020.00455 |
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