Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons

Oxidative stress is an important mechanism of neonatal hypoxic-ischemic brain damage. Sirtuin1 (Sirt1) is a deacetylase that depends on NAD(+), which has an important role in antioxidant metabolism. Furthermore, peroxisome proliferator-activated receptor γ-co-activator 1α (PGC-1α) is a key regulator...

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Detalles Bibliográficos
Publicado en:Front Pediatr
Autores principales: Shi, Lina, Zhang, Jing, Wang, Yan, Hao, Qingfei, Chen, Haoming, Cheng, Xiuyong
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Pediatrics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456989/
https://ncbi.nlm.nih.gov/pubmed/32923413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fped.2020.00455
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