Nlrp3 Inflammasome Signaling Regulates the Homing and Engraftment of Hematopoietic Stem Cells (HSPCs) by Enhancing Incorporation of CXCR4 Receptor into Membrane Lipid Rafts

Fast and efficient homing and engraftment of hematopoietic stem progenitor cells (HSPCs) is crucial for positive clinical outcomes from transplantation. We found that this process depends on activation of the Nlrp3 inflammasome, both in the HSPCs to be transplanted and in the cells in the recipient...

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Publicat a:Stem Cell Rev Rep
Autors principals: Adamiak, Mateusz, Abdel-Latif, Ahmed, Bujko, Kamila, Thapa, Arjun, Anusz, Krzysztof, Tracz, Michał, Brzezniakiewicz-Janus, Katarzyna, Ratajczak, Janina, Kucia, Magda, Ratajczak, Mariusz Z.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456406/
https://ncbi.nlm.nih.gov/pubmed/32661868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12015-020-10005-w
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