Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients

T cell immunity toward SARS-CoV-2 spike (S-), membrane (M-), and nucleocapsid (N-) proteins may define COVID-19 severity. Therefore, we compare the SARS-CoV-2-reactive T cell responses in moderate, severe, and critical COVID-19 patients and unexposed donors. Overlapping peptide pools of all three pr...

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Publicat a:Cell Rep Med
Autors principals: Thieme, Constantin J., Anft, Moritz, Paniskaki, Krystallenia, Blazquez-Navarro, Arturo, Doevelaar, Adrian, Seibert, Felix S., Hoelzer, Bodo, Konik, Margarethe Justine, Berger, Marc Moritz, Brenner, Thorsten, Tempfer, Clemens, Watzl, Carsten, Meister, Toni L., Pfaender, Stephanie, Steinmann, Eike, Dolff, Sebastian, Dittmer, Ulf, Westhoff, Timm H., Witzke, Oliver, Stervbo, Ulrik, Roch, Toralf, Babel, Nina
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456276/
https://ncbi.nlm.nih.gov/pubmed/32904468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100092
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