TPL2 enforces RAS-induced inflammatory signaling and is activated by point mutations

NF-κB transcription factors, driven by the IRAK/IKK cascade, confer treatment resistance in pancreatic ductal adenocarcinoma (PDAC), a cancer characterized by near-universal KRAS mutation. Through reverse-phase protein array and RNA sequencing we discovered that IRAK4 also contributes substantially...

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Udgivet i:J Clin Invest
Main Authors: Dodhiawala, Paarth B., Khurana, Namrata, Zhang, Daoxiang, Cheng, Yi, Li, Lin, Wei, Qing, Seehra, Kuljeet, Jiang, Hongmei, Grierson, Patrick M., Wang-Gillam, Andrea, Lim, Kian-Huat
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456254/
https://ncbi.nlm.nih.gov/pubmed/32573499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137660
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