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Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis
No known therapies can prevent anaphylaxis. Bruton’s tyrosine kinase (BTK) is an enzyme thought to be essential for high-affinity IgE receptor (FcεRI) signaling in human cells. We tested the hypothesis that FDA-approved BTK inhibitors (BTKis) would prevent IgE-mediated responses including anaphylaxi...
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| Pubblicato in: | J Clin Invest |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7456252/ https://ncbi.nlm.nih.gov/pubmed/32484802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138448 |
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