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p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease
Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the underlying mechanism and its pathogenic role remain elusive. We show that autophagy was inhibited in DKD models and in human diabetic kidneys. Ablation of autophagy-related gene 7 (Atg7) from kidney proximal tubul...
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| Vydáno v: | J Clin Invest |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7456229/ https://ncbi.nlm.nih.gov/pubmed/32804155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135536 |
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