p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease

Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the underlying mechanism and its pathogenic role remain elusive. We show that autophagy was inhibited in DKD models and in human diabetic kidneys. Ablation of autophagy-related gene 7 (Atg7) from kidney proximal tubul...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Ma, Zhengwei, Li, Lin, Livingston, Man J., Zhang, Dongshan, Mi, Qingsheng, Zhang, Ming, Ding, Han-Fei, Huo, Yuqing, Mei, Changlin, Dong, Zheng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456229/
https://ncbi.nlm.nih.gov/pubmed/32804155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135536
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