p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease

Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the underlying mechanism and its pathogenic role remain elusive. We show that autophagy was inhibited in DKD models and in human diabetic kidneys. Ablation of autophagy-related gene 7 (Atg7) from kidney proximal tubul...

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Vydáno v:J Clin Invest
Hlavní autoři: Ma, Zhengwei, Li, Lin, Livingston, Man J., Zhang, Dongshan, Mi, Qingsheng, Zhang, Ming, Ding, Han-Fei, Huo, Yuqing, Mei, Changlin, Dong, Zheng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456229/
https://ncbi.nlm.nih.gov/pubmed/32804155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135536
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