Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias

Connexin-43 (Cx43) gap junctions provide intercellular coupling, which ensures rapid action potential propagation and synchronized heart contraction. Alterations in Cx43 localization and reductions in gap junction coupling occur in failing hearts, contributing to ventricular arrhythmias and sudden c...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Xiao, Shaohua, Shimura, Daisuke, Baum, Rachel, Hernandez, Diana M., Agvanian, Sosse, Nagaoka, Yoshiko, Katsumata, Makoto, Lampe, Paul D., Kleber, Andre G., Hong, TingTing, Shaw, Robin M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456223/
https://ncbi.nlm.nih.gov/pubmed/32525845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134682
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