Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias

Connexin-43 (Cx43) gap junctions provide intercellular coupling, which ensures rapid action potential propagation and synchronized heart contraction. Alterations in Cx43 localization and reductions in gap junction coupling occur in failing hearts, contributing to ventricular arrhythmias and sudden c...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Principais autores: Xiao, Shaohua, Shimura, Daisuke, Baum, Rachel, Hernandez, Diana M., Agvanian, Sosse, Nagaoka, Yoshiko, Katsumata, Makoto, Lampe, Paul D., Kleber, Andre G., Hong, TingTing, Shaw, Robin M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456223/
https://ncbi.nlm.nih.gov/pubmed/32525845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134682
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