Long noncoding RNA H19X is a key mediator of TGF-β–driven fibrosis

TGF-β is a master regulator of fibrosis, driving the differentiation of fibroblasts into apoptosis-resistant myofibroblasts and sustaining the production of extracellular matrix (ECM) components. Here, we identified the nuclear long noncoding RNA (lncRNA) H19X as a master regulator of TGF-β–driven t...

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Pubblicato in:J Clin Invest
Autori principali: Pachera, Elena, Assassi, Shervin, Salazar, Gloria A., Stellato, Mara, Renoux, Florian, Wunderlin, Adam, Blyszczuk, Przemyslaw, Lafyatis, Robert, Kurreeman, Fina, de Vries-Bouwstra, Jeska, Messemaker, Tobias, Feghali-Bostwick, Carol A., Rogler, Gerhard, van Haaften, Wouter T., Dijkstra, Gerard, Oakley, Fiona, Calcagni, Maurizio, Schniering, Janine, Maurer, Britta, Distler, Jörg H.W., Kania, Gabriela, Frank-Bertoncelj, Mojca, Distler, Oliver
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456219/
https://ncbi.nlm.nih.gov/pubmed/32603313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135439
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