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Scaffold morphing of arbidol (umifenovir) in search of multi-targeting therapy halting the interaction of SARS-CoV-2 with ACE2 and other proteases involved in COVID-19

The rapid emergence of novel coronavirus, SARS-coronavirus 2 (SARS-CoV-2), originated from Wuhan, China, imposed a global health emergency. Angiotensin-converting enzyme 2 (ACE2) receptor serves as an entry point for this deadly virus while the proteases like furin, transmembrane protease serine 2 (...

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Bibliografske podrobnosti
izdano v:Virus Res
Main Authors: Choudhary, Shalki, Silakari, Om
Format: Artigo
Jezik:Inglês
Izdano: Elsevier B.V. 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455547/
https://ncbi.nlm.nih.gov/pubmed/32866534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2020.198146
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