Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

Breakdown of the blood-retinal barrier (BRB) causes retinal edema and vision loss. We investigated the role of Wnt signaling in maintaining the BRB by limiting transcytosis. Mice lacking either the Wnt co-receptor low-density lipoprotein receptor–related protein 5 (Lrp5(−/−)) or the Wnt ligand Norri...

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Publicat a:Sci Adv
Autors principals: Wang, Zhongxiao, Liu, Chi-Hsiu, Huang, Shuo, Fu, Zhongjie, Tomita, Yohei, Britton, William R., Cho, Steve S., Chen, Chuck T., Sun, Ye, Ma, Jian-xing, He, Xi, Chen, Jing
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455181/
https://ncbi.nlm.nih.gov/pubmed/32923627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba7457
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