Evaluating use cases for human challenge trials in accelerating SARS-CoV-2 vaccine development

Human challenge trials (HCTs) have been proposed as a means to accelerate SARS-CoV-2 vaccine development. We identify and discuss three potential use cases of HCTs in the current pandemic: evaluating efficacy, converging on correlates of protection, and improving understanding of pathogenesis and th...

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Veröffentlicht in:Clin Infect Dis
Hauptverfasser: Nguyen, Linh Chi, Bakerlee, Christopher W, McKelvey, T Greg, Rose, Sophie M, Norman, Alexander J, Joseph, Nicholas, Manheim, David, McLaren, Michael R, Jiang, Steven, Barnes, Conor F, Kinniment, Megan, Foster, Derek, Darton, Thomas C, Morrison, Josh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Review Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454474/
https://ncbi.nlm.nih.gov/pubmed/32628748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciaa935
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