Location of Stimuli-Responsive Peptide Sequences within Silk-Elastinlike Protein-Based Polymers Affects Nanostructure Assembly and Drug-Polymer Interactions

Silk-elastinlike protein polymers (SELPs) self-assemble into nanostructures when designed with appropriate silk-to-elastin ratios. Here, we investigate the effect of insertion of a matrix metalloproteinase-responsive peptide sequence, GPQGIFGQ, into various locations within the SELP backbone on supr...

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Veröffentlicht in:J Drug Target
Hauptverfasser: Isaacson, Kyle J., Jensen, M. Martin, Steinhauff, Douglas B., Kirklow, James E., Mohammadpour, Raziye, Grunberger, Jason W., Cappello, Joseph, Ghandehari, Hamidreza
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454231/
https://ncbi.nlm.nih.gov/pubmed/32306773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/1061186X.2020.1757099
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