Adipostatins E-J, New Potent Antimicrobials Identified as Inhibitors of Coenzyme-A Biosynthesis

Phosphopantetheine is a key structural element in biological acyl transfer reactions found embedded within coenzyme A (CoA). Phosphopantothenoylcysteine synthetase (PPCS) is responsible for installing a cysteamine group within phosphopantetheine. Therefore, it holds considerable potential as a drug...

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發表在:Tetrahedron Lett
Main Authors: Gómez-Rodríguez, Lyanne, Schultz, Pamela J., Tamayo-Castillo, Giselle, Dotson, Garry D., Sherman, David H., Tripathi, Ashootosh
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453842/
https://ncbi.nlm.nih.gov/pubmed/32863451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2019.151469
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