Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression in prostate cancer. Here we report that metabolomic profiling of longitudinal plasmas from a prospective cohort of 491 active surveillance (AS) participants indicates prominent elevations in plasma sphingolipids in AS progressor...

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Published in:Nat Commun
Main Authors: Vykoukal, Jody, Fahrmann, Johannes F., Gregg, Justin R., Tang, Zhe, Basourakos, Spyridon, Irajizad, Ehsan, Park, Sanghee, Yang, Guang, Creighton, Chad J., Fleury, Alia, Mayo, Jeffrey, Paulucci-Holthauzen, Adriana, Dennison, Jennifer B., Murage, Eunice, Peterson, Christine B., Davis, John W., Kim, Jeri, Hanash, Samir, Thompson, Timothy C.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453025/
https://ncbi.nlm.nih.gov/pubmed/32855410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17645-z
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