Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike

There are no approved target therapeutics against SARS-CoV-2 or other beta-CoVs. The beta-CoV Spike protein is a promising target considering the critical role in viral infection and pathogenesis and its surface exposed features. We performed a structure-based strategy targeting highly conserved dru...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Trigueiro-Louro, João, Correia, Vanessa, Figueiredo-Nunes, Inês, Gíria, Marta, Rebelo-de-Andrade, Helena
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452956/
https://ncbi.nlm.nih.gov/pubmed/32913581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.07.017
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