High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain

BACKGROUND: The insulin-sensitizing phytocannabinoid, Δ(9)-tetrahydrocannabivarin (THCV) can signal partly via G-protein coupled receptor-55 (GPR55 behaving as either an agonist or an antagonist depending on the assay). The cannabinoid receptor type 1 (CB1R) inverse agonist rimonabant is also a GPR5...

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Vydáno v:PeerJ
Hlavní autoři: Wargent, Edward T., Kepczynska, Malgorzata, Zaibi, Mohamed Sghaier, Hislop, David C., Arch, Jonathan R.S., Stocker, Claire J.
Médium: Artigo
Jazyk:Inglês
Vydáno: PeerJ Inc. 2020
Témata:
Biochemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7451014/
https://ncbi.nlm.nih.gov/pubmed/32904155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9811
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