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Scaffold-hopping as a strategy to address metabolic liabilities of aromatic compounds
Understanding and minimizing oxidative metabolism of aromatic compounds is a key hurdle in lead optimization. Metabolic processes not only clear compounds from the body, but they can also transform parent compounds into reactive metabolites. One particularly useful strategy when addressing metabolic...
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| Publicado no: | RSC Med Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7451012/ https://ncbi.nlm.nih.gov/pubmed/33479602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00396g |
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