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Rigid Scaffolds: Synthesis of 2,6‐Bridged Piperazines with Functional Groups in all three Bridges
The activity of pharmacologically active compounds can be increased by presenting a drug in a defined conformation, which fits exactly into the binding pocket of its target. Herein, the piperazine scaffold was conformationally restricted by substituted C(2)‐ or C(3)‐bridges across the 2‐ and 6‐posit...
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| 出版年: | ChemistryOpen |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7450790/ https://ncbi.nlm.nih.gov/pubmed/32884883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.202000188 |
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