Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells

The insulinotropic actions of glucagon-like peptide 1 receptor (GLP-1R) in β-cells have made it a useful target to manage type 2 diabetes. Metabolic stress reduces β-cell sensitivity to GLP-1, yet the underlying mechanisms are unknown. We hypothesized that Glp1r expression is heterogeneous among β-c...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gray, Sarah M., Xin, Yurong, Ross, Elizabeth C., Chazotte, Bryanna M., Capozzi, Megan E., El, Kimberley, Svendsen, Berit, Ravn, Peter, Sloop, Kyle W., Tong, Jenny, Gromada, Jesper, Campbell, Jonathan E., D'Alessio, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450118/
https://ncbi.nlm.nih.gov/pubmed/32554468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014368
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