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Transient intracellular acidification regulates the core transcriptional heat shock response
Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thought to depend on ongoing protein synthesis. Here,...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7449696/ https://ncbi.nlm.nih.gov/pubmed/32762843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54880 |
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