Effect of Systemic Inflammatory Response to SARS-CoV-2 on Lopinavir and Hydroxychloroquine Plasma Concentrations

Coronavirus disease 2019 (COVID-19) leads to inflammatory cytokine release, which can downregulate the expression of metabolizing enzymes. This cascade affects drug concentrations in the plasma. We investigated the association between lopinavir (LPV) and hydroxychloroquine (HCQ) plasma concentration...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Marzolini, Catia, Stader, Felix, Stoeckle, Marcel, Franzeck, Fabian, Egli, Adrian, Bassetti, Stefano, Hollinger, Alexa, Osthoff, Michael, Weisser, Maja, Gebhard, Caroline E., Baettig, Veronika, Geenen, Julia, Khanna, Nina, Tschudin-Sutter, Sarah, Mueller, Daniel, Hirsch, Hans H., Battegay, Manuel, Sendi, Parham
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449226/
https://ncbi.nlm.nih.gov/pubmed/32641296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01177-20
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