Therapeutic Efficacy of Novel Antimicrobial Peptide AA139-Nanomedicines in a Multidrug-Resistant Klebsiella pneumoniae Pneumonia-Septicemia Model in Rats

Antimicrobial peptides (AMPs) have seen limited clinical use as antimicrobial agents, largely due to issues relating to toxicity, short biological half-life, and lack of efficacy against Gram-negative bacteria. However, the development of novel AMP-nanomedicines, i.e., AMPs entrapped in nanoparticle...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: van der Weide, Hessel, Cossío, Unai, Gracia, Raquel, te Welscher, Yvonne M., ten Kate, Marian T., van der Meijden, Aart, Marradi, Marco, Ritsema, Jeffrey A. S., Vermeulen-de Jongh, Denise M. C., Storm, Gert, Goessens, Wil H. F., Loinaz, Iraida, van Nostrum, Cornelus F., Llop, Jordi, Hays, John P., Bakker-Woudenberg, Irma A. J. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449162/
https://ncbi.nlm.nih.gov/pubmed/32540976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00517-20
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