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A Highly Prevalent Polymorphism in the Core Region Impairs Quantification of Hepatitis B Virus (HBV) by the cobas TaqMan HBV Assay

The high genetic variability of hepatitis B virus (HBV) can impair DNA quantification. Here, we investigate a major underquantification of HBV by the cobas TaqMan HBV assay (CTM; Roche). In France, between 2005 and 2017, HBV DNA was detected in 3,102 blood donations by use of the CTM (95% limit of d...

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Bibliografische gegevens
Gepubliceerd in:J Clin Microbiol
Hoofdauteurs: Boizeau, Laure, Servant-Delmas, Annabelle, Ducancelle, Alexandra, Chevaliez, Stéphane, Thibault, Vincent, Laperche, Syria, Cappy, Pierre
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448625/
https://ncbi.nlm.nih.gov/pubmed/32669381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00647-20
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