Synthesis of N,N′-bis(1,5-dimethyl-2-phenyl-1,2-dihydro-3-oxopyrazol-4-yl) sebacamide that ameliorate osteoarthritis symptoms and improve bone marrow matrix structure and cartilage alterations induced by monoiodoacetate in the rat model: “Suggested potent anti-inflammatory agent against COVID-19”

To assess the chondroprotective effect and influence of N,N′-bis(1,5-dimethyl-2-phenyl-1,2-dihydro-3-oxopyrazol-4-yl) sebacamide (dpdo) that was synthesized through the reaction of phenazone with sebacoyl chloride and screened for its biological activity especially as anti-arthritic and anti-inflamm...

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Detalhes bibliográficos
Publicado no:Hum Exp Toxicol
Main Authors: Refat, MS, Hamza, RZ, Adam, AMA, Saad, HA, Gobouri, AA, Al-Salmi, FA, Altalhi, T, El-Megharbel, SM
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447864/
https://ncbi.nlm.nih.gov/pubmed/32840387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0960327120945779
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