MGMT promoter methylation in triple negative breast cancer of the GeparSixto trial

Triple-negative breast cancer (TNBC) is typically treated with chemotherapeutic agents, including carboplatin (Cb), an DNA platinating agent. The O6-methylguanine-DNA-methyltransferase gene (MGMT) encodes for the protein O6-alkylguanine-DNA-alkyltransferase (MGMT protein). MGMT protein is involved i...

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Vydáno v:PLoS One
Hlavní autoři: Jank, Paul, Gehlhaar, Claire, Bianca, Lederer, Caterina, Fontanella, Andreas, Schneeweiss, Karn, Thomas, Marmé, Frederik, Sinn, Hans-Peter, van Mackelenbergh, Marion, Sinn, Bruno, Zahm, Dirk-Michael, Ingold-Heppner, Barbara, Schem, Christian, Stickeler, Elmar, Fasching, Peter A., Nekljudova, Valentina, Taube, Eliane Tabea, Heppner, Frank, Müller, Volkmar, Denkert, Carsten, Loibl, Sibylle
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446962/
https://ncbi.nlm.nih.gov/pubmed/32841306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0238021
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