Phase I Study of the BRAF Inhibitor Vemurafenib in Combination With the Mammalian Target of Rapamycin Inhibitor Everolimus in Patients With BRAF-Mutated Malignancies

PURPOSE: Parallel activation of the phosphatidylinositol 3-kinase–mammalian target of rapamycin pathway represents a mechanism of primary and acquired resistance to BRAF-targeted therapy, but the two pathways have yet to be cotargeted in humans. We performed a phase I study to evaluate the safety an...

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Pubblicato in:JCO Precis Oncol
Autori principali: Subbiah, Vivek, Sen, Shiraj, Hess, Kenneth R., Janku, Filip, Hong, David S., Khatua, Soumen, Karp, Daniel D., Munoz, Javier, Falchook, Gerald S., Groisberg, Roman, Tsimberidou, Apostolia M., Sherman, Steven I., Hwu, Patrick, Meric-Bernstam, Funda
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2018
Soggetti:
Original Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446411/
https://ncbi.nlm.nih.gov/pubmed/32913986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00189
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