The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy

ABSTRACT: Chimeric Antigen Receptor (CAR) immunotherapy utilizes genetically-engineered immune cells that express a unique cell surface receptor that combines tumor antigen specificity with immune cell activation. In recent clinical trials, the adoptive transfer of CAR-modified immune cells (includi...

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Publicado en:Cell Commun Signal
Autores principales: Liu, Dongfang, Badeti, Saiaditya, Dotti, Gianpietro, Jiang, Jie-gen, Wang, He, Dermody, James, Soteropoulos, Patricia, Streck, Deanna, Birge, Raymond B., Liu, Chen
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446110/
https://ncbi.nlm.nih.gov/pubmed/32843053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00617-7
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