DNA damage response and preleukemic fusion genes induced by ionizing radiation in umbilical cord blood hematopoietic stem cells

There is clear evidence that ionizing radiation (IR) causes leukemia. For many types of leukemia, the preleukemic fusion genes (PFG), as consequences of DNA damage and chromosomal translocations, occur in hematopoietic stem and progenitor cells (HSPC) in utero and could be detected in umbilical cord...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kosik, Pavol, Durdik, Matus, Jakl, Lukas, Skorvaga, Milan, Markova, Eva, Vesela, Gabriela, Vokalova, Lenka, Kolariková, Lucia, Horvathova, Eva, Kozics, Katarina, Belyaev, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7445283/
https://ncbi.nlm.nih.gov/pubmed/32839487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70657-z
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