Stem cell mobilization with plerixafor and healing of diabetic ischemic wounds: A phase IIa, randomized, double‐blind, placebo‐controlled trial

Bone marrow‐derived cells contribute to tissue repair, but traffic of hematopoietic stem/progenitor cells (HSPCs) is impaired in diabetes. We therefore tested whether HSPC mobilization with the CXCR4 antagonist plerixafor improved healing of ischemic diabetic wounds. This was a pilot, phase IIa, dou...

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Veröffentlicht in:Stem Cells Transl Med
Hauptverfasser: Bonora, Benedetta Maria, Cappellari, Roberta, Mazzucato, Marta, Rigato, Mauro, Grasso, Marco, Menegolo, Mirko, Bruttocao, Andrea, Avogaro, Angelo, Fadini, Gian Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2020
Schlagworte:
Human Clinical Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7445026/
https://ncbi.nlm.nih.gov/pubmed/32485785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.20-0020
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