OVERCOMING UNDERPOWERING: TRIAL SIMULATIONS AND A GLOBAL RANK ENDPOINT TO OPTIMIZE CLINICAL TRIALS IN CHILDREN WITH HEART DISEASE

BACKGROUND: Randomized controlled trials (RCTs) in children with heart disease are challenging and therefore infrequently performed. We sought to improve feasibility of perioperative RCTs for this patient cohort using data from a large, multi-center clinical registry. We evaluated potential enrollme...

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Detalhes bibliográficos
Publicado no:Am Heart J
Main Authors: Hill, Kevin D., Baldwin, H. Scott, Bichel, David P., Ellis, Alicia M., Graham, Eric M., Hornik, Christoph P., Jacobs, Jeffrey P., Jaquiss, Robert D. B., Jacobs, Marshall L., Kannankeril, Prince J., Li, Jennifer S., Torok, Rachel, Turek, Joseph W., O’Brien, Sean M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442685/
https://ncbi.nlm.nih.gov/pubmed/32599259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ahj.2020.05.011
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