Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

Identification of targeted therapies for TNBC is an urgent medical need. Using a drug combination screen reliant on synthetic lethal interactions, we identified clinically relevant combination therapies for different TNBC subtypes. Two drug combinations targeting the BET family were further explored...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Verma, Nandini, Vinik, Yaron, Saroha, Ashish, Nair, Nishanth Ulhas, Ruppin, Eytan, Mills, Gordon, Karn, Thomas, Dubey, Vinay, Khera, Lohit, Raj, Harsha, Maina, Flavio, Lev, Sima
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442484/
https://ncbi.nlm.nih.gov/pubmed/32937365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba8968
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