Synthesis and Structure–Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents

Currently, due to the HIV latency mechanism, the search continues for effective drugs to combat this issue and provide a cure for AIDS. Gnidimacrin activates latent HIV-1 replication and inhibits HIV-1 infection at picomolar concentrations. This natural diterpene was able to markedly reduce the late...

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發表在:J Med Chem
Main Authors: Liu, Qingbo, Cheng, Yung-Yi, Li, Wei, Huang, Li, Asada, Yoshihisa, Hsieh, Min-Tsang, Morris-Natschke, Susan L., Chen, Chin-Ho, Koike, Kazuo, Lee, Kuo-Hsiung
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442216/
https://ncbi.nlm.nih.gov/pubmed/31343875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00339
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