Variability in retinoblastoma genome stability is driven by age and not heritability

Retinoblastoma (RB) is a childhood intraocular cancer initiated by biallelic inactivation of the RB tumor suppressor gene (RB1(−/−)). RB can be hereditary (germline RB1 pathogenic allele is present) or non-hereditary. Somatic copy number alterations (SCNAs) contribute to subsequent tumorigenesis. Pr...

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Bibliographic Details
Published in:Genes Chromosomes Cancer
Main Authors: Polski, Ashley, Xu, Liya, Prabakar, Rishvanth K., Gai, Xiaowu, Kim, Jonathan W., Shah, Rachana, Jubran, Rima, Kuhn, Peter, Cobrinik, David, Hicks, James, Berry, Jesse L.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441809/
https://ncbi.nlm.nih.gov/pubmed/32390242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22859
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