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Variability in retinoblastoma genome stability is driven by age and not heritability
Retinoblastoma (RB) is a childhood intraocular cancer initiated by biallelic inactivation of the RB tumor suppressor gene (RB1(−/−)). RB can be hereditary (germline RB1 pathogenic allele is present) or non-hereditary. Somatic copy number alterations (SCNAs) contribute to subsequent tumorigenesis. Pr...
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| Publicado no: | Genes Chromosomes Cancer |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7441809/ https://ncbi.nlm.nih.gov/pubmed/32390242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22859 |
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