Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression

Exome sequencing has identified the glyceronephosphate O-acyltransferase (GNPAT) gene as a genetic modifier of iron overload in hereditary hemochromatosis (HH). Subjects with HFE (Homeostatic Iron Regulator) p.C282Y mutations and the GNPAT p.D519G variant had more iron loading compared with subjects...

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Podrobná bibliografie
Vydáno v:Biosci Rep
Hlavní autoři: Rishi, Gautam, Secondes, Eriza S., Asplett, Kiran, Wallace, Daniel F., Ostini, Lesa, Berger, Johannes, Subramaniam, V. Nathan
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2020
Témata:
Gastrointestinal, Renal & Hepatic Systems
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441371/
https://ncbi.nlm.nih.gov/pubmed/32766721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20201508
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