Effects of empagliflozin and target-organ damage in a novel rodent model of heart failure induced by combined hypertension and diabetes

Type 2 diabetes mellitus and hypertension are two major risk factors leading to heart failure and cardiovascular damage. Lowering blood sugar by the sodium-glucose co-transporter 2 inhibitor empagliflozin provides cardiac protection. We established a new rat model that develops both inducible diabet...

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Pubblicato in:Sci Rep
Autori principali: Kräker, Kristin, Herse, Florian, Golic, Michaela, Reichhart, Nadine, Crespo-Garcia, Sergio, Strauß, Olaf, Grune, Jana, Kintscher, Ulrich, Ebrahim, Manal, Bader, Michael, Alenina, Natalia, Heuser, Arnd, Luft, Friedrich C., Müller, Dominik N., Dechend, Ralf, Haase, Nadine
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441148/
https://ncbi.nlm.nih.gov/pubmed/32820187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70708-5
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