Streptozotocin Induces Alzheimer’s Disease-Like Pathology in Hippocampal Neuronal Cells via CDK5/Drp1-Mediated Mitochondrial Fragmentation

Aberrant brain insulin signaling plays a critical role in the pathology of Alzheimer’s disease (AD). Mitochondrial dysfunction plays a role in the progression of AD, with excessive mitochondrial fission in the hippocampus being one of the pathological mechanisms of AD. However, the molecular mechani...

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Pubblicato in:Front Cell Neurosci
Autori principali: Park, Junghyung, Won, Jinyoung, Seo, Jincheol, Yeo, Hyeon-Gu, Kim, Keonwoo, Kim, Yu Gyeong, Jeon, Chang-Yeop, Kam, Min Kyoung, Kim, Young-Hyun, Huh, Jae-Won, Lee, Sang-Rae, Lee, Dong-Seok, Lee, Youngjeon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Cellular Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438738/
https://ncbi.nlm.nih.gov/pubmed/32903692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00235
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