Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability

Maintaining biocatalyst stability and activity is a critical challenge. Chondroitinase ABC (ChABC) has shown promise in central nervous system (CNS) regeneration, yet its therapeutic utility is severely limited by instability. We computationally reengineered ChABC by introducing 37, 55, and 92 amino...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Hettiaratchi, Marian H., O’Meara, Matthew J., O’Meara, Teresa R., Pickering, Andrew J., Letko-Khait, Nitzan, Shoichet, Molly S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438101/
https://ncbi.nlm.nih.gov/pubmed/32875119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc6378
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