Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability

Maintaining biocatalyst stability and activity is a critical challenge. Chondroitinase ABC (ChABC) has shown promise in central nervous system (CNS) regeneration, yet its therapeutic utility is severely limited by instability. We computationally reengineered ChABC by introducing 37, 55, and 92 amino...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Hettiaratchi, Marian H., O’Meara, Matthew J., O’Meara, Teresa R., Pickering, Andrew J., Letko-Khait, Nitzan, Shoichet, Molly S.
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438101/
https://ncbi.nlm.nih.gov/pubmed/32875119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc6378
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