In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics

Drug resistance is a core issue in cancer chemotherapy. A known folate antagonist, methotrexate (MTX) inhibits human dihydrofolate reductase (hDHFR), the enzyme responsible for the catalysis of 7,8-dihydrofolate reduction to 5,6,7,8-tetrahydrofolate, in biosynthesis and cell proliferation. Structura...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Molecules
मुख्य लेखकों: Rana, Rabia Mukhtar, Rampogu, Shailima, Abid, Noman Bin, Zeb, Amir, Parate, Shraddha, Lee, Gihwan, Yoon, Sanghwa, Kim, Yumi, Kim, Donghwan, Lee, Keun Woo
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: MDPI 2020
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7435474/
https://ncbi.nlm.nih.gov/pubmed/32752079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25153510
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