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Key role of quinone in the mechanism of respiratory complex I

Complex I is the first and the largest enzyme of respiratory chains in bacteria and mitochondria. The mechanism which couples spatially separated transfer of electrons to proton translocation in complex I is not known. Here we report five crystal structures of T. thermophilus enzyme in complex with...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gutiérrez-Fernández, Javier, Kaszuba, Karol, Minhas, Gurdeep S., Baradaran, Rozbeh, Tambalo, Margherita, Gallagher, David T., Sazanov, Leonid A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434922/
https://ncbi.nlm.nih.gov/pubmed/32811817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17957-0
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