Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils

Modulation of immunity and disease by glycans is increasingly recognized. However, how host glycosylation shapes and is shaped by tuberculosis remains poorly understood. We show that deficiency in the glucosaminyl (N-acetyl) transferase 1 (Gcnt1), a key enzyme for core-2 O-glycans biosynthesis, driv...

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Udgivet i:Mucosal Immunol
Main Authors: Fonseca, Kaori L., Maceiras, Ana Raquel, Matos, Rita, Simoes-Costa, Luisa, Sousa, Jeremy, Cá, Baltazar, Barros, Leandro, Fernandes, Ana Isabel, Mereiter, Stefan, Reis, Ricardo, Gomes, Joana, Tapia, Gustavo, Rodríguez-Martínez, Paula, Martín-Céspedes, Montse, Vashakidze, Sergo, Gogishvili, Shota, Nikolaishvili, Keti, Appelberg, Rui, Gärtner, Fátima, Rodrigues, Pedro N. S., Vilaplana, Cristina, Reis, Celso A., Magalhães, Ana, Saraiva, Margarida
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group US 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434595/
https://ncbi.nlm.nih.gov/pubmed/32203062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-020-0277-7
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