Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils

Modulation of immunity and disease by glycans is increasingly recognized. However, how host glycosylation shapes and is shaped by tuberculosis remains poorly understood. We show that deficiency in the glucosaminyl (N-acetyl) transferase 1 (Gcnt1), a key enzyme for core-2 O-glycans biosynthesis, driv...

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Bibliografski detalji
Izdano u:Mucosal Immunol
Glavni autori: Fonseca, Kaori L., Maceiras, Ana Raquel, Matos, Rita, Simoes-Costa, Luisa, Sousa, Jeremy, Cá, Baltazar, Barros, Leandro, Fernandes, Ana Isabel, Mereiter, Stefan, Reis, Ricardo, Gomes, Joana, Tapia, Gustavo, Rodríguez-Martínez, Paula, Martín-Céspedes, Montse, Vashakidze, Sergo, Gogishvili, Shota, Nikolaishvili, Keti, Appelberg, Rui, Gärtner, Fátima, Rodrigues, Pedro N. S., Vilaplana, Cristina, Reis, Celso A., Magalhães, Ana, Saraiva, Margarida
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group US 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434595/
https://ncbi.nlm.nih.gov/pubmed/32203062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-020-0277-7
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