Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) region of the genome have been detected in Singapore and other countries. We investigated the effect of this deletion on the clinical features of...

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Publicado no:Lancet
Main Authors: Young, Barnaby E, Fong, Siew-Wai, Chan, Yi-Hao, Mak, Tze-Minn, Ang, Li Wei, Anderson, Danielle E, Lee, Cheryl Yi-Pin, Amrun, Siti Naqiah, Lee, Bernett, Goh, Yun Shan, Su, Yvonne C F, Wei, Wycliffe E, Kalimuddin, Shirin, Chai, Louis Yi Ann, Pada, Surinder, Tan, Seow Yen, Sun, Louisa, Parthasarathy, Purnima, Chen, Yuan Yi Constance, Barkham, Timothy, Lin, Raymond Tzer Pin, Maurer-Stroh, Sebastian, Leo, Yee-Sin, Wang, Lin-Fa, Renia, Laurent, Lee, Vernon J, Smith, Gavin J D, Lye, David Chien, Ng, Lisa F P
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434477/
https://ncbi.nlm.nih.gov/pubmed/32822564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(20)31757-8
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