Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis

Stem cell-derived β (SC-β) cells could provide unlimited human β cells toward a curative diabetes treatment. Differentiation of SC-β cells yields transplantable islets that secrete insulin in response to glucose challenges. Following transplantation into mice, SC-β cell function is comparable to hum...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Davis, Jeffrey C., Alves, Tiago C., Helman, Aharon, Chen, Jonathan C., Kenty, Jennifer H., Cardone, Rebecca L., Liu, David R., Kibbey, Richard G., Melton, Douglas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433758/
https://ncbi.nlm.nih.gov/pubmed/32402282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107623
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