Copper(II) L/D-valine-(1,10-phen) Complexes Target Human Telomeric G-quadruplex Motifs and Promote Site-Specific DNA Cleavage and Cellular Cytotoxicity

Chiral L-/D-valine-(1,10-phen)-Cu(II) complexes that target G-quadruplex DNA were synthesized and thoroughly characterized by UV−vis, IR, EPR, ESI-MS, elemental analysis and single crystal X–ray spectroscopy. Complexes 1a and 1b crystallized in the monoclinic P21/c and C2 space groups, respectively....

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Bibliographic Details
Published in:Dalton Trans
Main Authors: Arjmand, Farukh, Sharma, Surbhi, Parveen, Sabiha, Toupet, Loic, Yu, Zhen, Cowan, J. A.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433390/
https://ncbi.nlm.nih.gov/pubmed/32638779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0dt01527j
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