Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed βH-Crystallins Polymerization in Calcium-Induced Experimental Cataract

In an in vitro Ca(2+)-induced cataract model, the progression of opacification is paralleled by a rapid decrease of the endogenous levels of spermidine (SPD) and an increase of transglutaminase type 2 (TG2, EC 2.3.2.13)-catalyzed lens crystallins cross-linking by protein-bound N(1)-N(8)-bis(γ-glutam...

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Publicat a:Int J Mol Sci
Autors principals: Mischiati, Carlo, Feriotto, Giordana, Tabolacci, Claudio, Domenici, Fabio, Melino, Sonia, Borromeo, Ilaria, Forni, Cinzia, De Martino, Angelo, Beninati, Simone
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7432200/
https://ncbi.nlm.nih.gov/pubmed/32751462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21155427
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