Reduced Calcium Signaling Is Associated With Severe Graft-Versus-Host Disease: Results From Preclinical Models and From a Prospective EBMT Study

Despite its involvement in various immune functions, including the allogeneic activation of T-lymphocytes, the relevance of calcium (Ca(2+)) for GVHD pathobiology is largely unknown. To elucidate a potential association between Ca(2+)and GVHD, we analyzed Ca(2+)-sensing G-protein coupled receptor 6a...

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Pubblicato in:Front Immunol
Autori principali: Riesner, Katarina, Cordes, Steffen, Peczynski, Christophe, Kalupa, Martina, Schwarz, Constanze, Shi, Yu, Mertlitz, Sarah, Mengwasser, Jörg, van der Werf, Steffie, Peric, Zinaida, Koenecke, Christian, Schoemans, Helene, Duarte, Rafael F., Basak, Grzegorz W., Penack, Olaf
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7431962/
https://ncbi.nlm.nih.gov/pubmed/32849661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01983
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